Genesis Mission: The Great American Pivot Worthy of America's Pride

Bryant McGill · Genesis Mission: The Great American Pivot Worthy of America's Pride

**How the Genesis Mission Transformed a Nation's Trajectory** ## The Genesis Mission: America Wakes Up Five days ago, something extraordinary happened. On November 24, 2025, President Trump signed an executive order that may well mark the most significant pivot in American strategic positioning since the Manhattan Project. The Genesis Mission—a name deliberately chosen to echo both biblical creation and Apollo-era ambition—mobilizes America's seventeen national laboratories, world-leading supercomputers, and vast federal datasets into a unified AI platform designed to accelerate scientific discovery from years to days. The scale is staggering. Oak Ridge, Livermore, Argonne, Los Alamos—these quiet cathedrals of American genius that I eulogized in "[The Hidden Heart of America: Why Our National Labs Are the Only Real Patriots Left](https://bryantmcgill.blogspot.com/2023/07/the-hidden-heart-of-america-why-our.html)" are now being flooded with exaflops of compute power, stripped of their legacy regulatory barnacles, and given a Manhattan-Project-sized mandate: solve energy, solve materials, solve biology, solve security—and do it faster than any civilization in history has ever solved anything. The priority domains read like a blueprint for species-level survival: nuclear fission and fusion energy, biotechnology, critical materials, quantum information science, semiconductors, and space exploration. These aren't abstract research directions. They're the exact technological capabilities required for civilization to transcend the thermodynamic constraints I've been warning about for two years. The Department of Energy is already partnering with AMD to launch next-generation supercomputers—"Solstice" at Argonne, "Discovery" at Oak Ridge—systems that will dwarf even Frontier's capabilities. The closed-loop AI experimentation platform will automate experiment design, accelerate simulations, and generate predictive models for everything from protein folding to fusion plasma dynamics. Research that once took years could now take hours. This is not incremental progress. This is America declaring that it will not sleepwalk into obsolescence. This is the nation that built the atomic bomb, landed on the moon, and invented the internet deciding—finally, decisively—to compete for the future rather than mortgage it. ## The Warnings That Made This Necessary The Genesis Mission didn't emerge from thin air. It emerged from crisis—the very crisis I spent two years documenting in essays that read, in retrospect, like dispatches from a nation flirting with self-destruction. In January 2025, I published "[Left Behind: America Is Actually Choosing to Miss the Fourth Industrial Revolution](https://bryantmcgill.blogspot.com/2025/01/left-behind-rejects-america-is-actually.html)"—a dissection of how the United States was voluntarily ceding technological leadership while Japan rolled out Society 5.0 exoskeletons and Shenzhen built cities that thought faster than most American states could pass a budget. That same month, "[America in the Mirror of Global Interdependence](https://bryantmcgill.blogspot.com/2025/01/america-in-mirror-of-global.html)" exposed "America First" for what it too often was: a rhetorical comfort blanket masking our catastrophic unwillingness to admit we no longer manufacture our own critical technologies. "[The Duality of Rhetoric and Action](https://xentities.blogspot.com/2025/01/the-duality-of-rhetoric-and-action-in.html)" warned that nationalism without corresponding competence was performative cosplay—theater substituting for substance. By March, I was writing about thermodynamic inevitability—the iron laws of physics that don't negotiate with ideology "[The Doomed West's Last AI Illusion](https://bryantmcgill.blogspot.com/2025/03/the-doomed-wests-last-ai-illusion-why.html)". The relay baton of human genius, I warned, was being fumbled not because of malice but because of complacency, distraction, and institutional paralysis. **The dangers were real enough that I advised people to prepare for the worst.** In April 2025, I published "[Last Call for Safe Passage: Preparing for America's Great Realignment](https://bryantmcgill.blogspot.com/2025/04/last-call-for-safe-passage-preparing.html)"—laying out contingency plans for readers who feared the country might collapse **into an anti-Semitic hotbed of nationalist and anti-science entropy**. I urged people to secure passports, update vaccinations, and position themselves in more stable regions: Israel (cited as the first and most critical option, emphasized for its proven “hardened state” capacity to maintain technological and existential resilience under pressure), EU (widely regarded as a stronghold), Singapore, Japan, Zurich, Dubai. For those determined to remain, I identified American cities and territories with the strongest resilience vectors—Seattle, Portland, New York, Puerto Rico's emerging tech scene, the Cascadia region's cultural openness and Pacific connectivity. I wasn't being alarmist. I was being realistic. The signals of major upheaval were multiplying faster than institutional responses could address them. The Trump administration's nationalist posture—marked by withdrawal from global frameworks, institutional disruption, and antagonism toward scientific cooperation—appeared to be accelerating conditions for systemic implosion. Every indicator I tracked pointed toward managed collapse or drastic realignment. And hovering above all of this was a signal so ancient, so historically consistent, that it should have frozen the blood of any serious observer: the eruption of open anti-Semitism on American college campuses. They wrapped themselves in the aesthetic codes of a global insurgency, as if unaware of the lineage they were invoking—or, more disturbingly, fully aware. The keffiyeh, which they brandished as a fashionable token of “resistance,” is not a neutral garment. It is the chosen insignia of an entire era of militant politics: Osama bin Laden wore it. So did the Boston Marathon bombers. So did the Parliament Hill shooter in Ottawa. So did Yahya Sinwar as he orchestrated the slaughter of October 7th. Members of ISIS wore it. Leila Khaled wore it when she hijacked planes in the name of “liberation.” Even Moammar Gadhafi adorned himself with it as he framed terrorism as revolution. Symbols matter because they communicate political lineage. And these students—whether naïve or intentional—were aligning themselves with a century of anti-democratic, anti-Semitic, explicitly violent movements that have sought to dismantle the liberal West from within. The so-called “pro-Palestinian” encampments were not expressions of geopolitical concern; they were rehearsals in ideological intimidation, aimed at a minority population that has always served as the early-warning system of civilizational decline. I said then—and I say again now—that when a nation’s elite institutions allow Jewish students to be harassed, hunted, or silenced, the society is already in moral freefall. Anti-Semitism is never an isolated prejudice. It is a structural indicator, a diagnostic of failing cultural immune systems, a signpost that the civic order is losing its coherence. Once that line is crossed, history shows, collapse is no longer hypothetical; it becomes a trajectory. Those warnings were not wrong. They remain historically accurate assessments of where America stood eighteen months ago. What I could not fully see was the parallel track of preparation already underway beneath the chaos. ## What I Saw—and What I Missed In July 2025, I published "[Stargate: Understanding Politics and Strategy Behind Trump's AI Supercomputer Vision](https://bryantmcgill.blogspot.com/2025/07/stargate-understanding-politics-and.html)"—an attempt to translate the strategic logic I could glimpse beneath the rhetorical noise. I saw early outlines of what would become Genesis: a president who understood that AI dominance was inseparable from energy dominance, who was willing to spend political capital on exascale infrastructure at unprecedented scale, and who grasped that national laboratories were the only institutions large enough, trusted enough, and competent enough to execute something this ambitious without leaking it to hedge funds first. That essay wasn't prophecy. It was pattern recognition—connecting the dots between energy policy, computational infrastructure, and civilizational trajectory. The Stargate project's \$500 billion AI infrastructure investment, the partnership announcements with AMD and Nvidia, the quiet appropriations riders and interagency coordination—these were data points suggesting preparation for something far more ambitious than conventional policy. In June 2025, I published "[Democracy's Successor: How Charter Cities Could Reshape America and the World](https://bryantmcgill.blogspot.com/2025/06/democracys-successor-how-charter-cities.html)"—wrestling with what appeared, on the surface, like a barrage of troubling constitutional adjustments. Challenges to birthright citizenship, the evisceration of DEI frameworks, Schedule F's revival of at-will federal employment, the aggressive repurposing of federal lands—these policies struck many, myself included at first glance, as raw authoritarian overreach. But as I dug deeper, a larger architecture emerged. These weren't isolated salvos in a culture war. They were legal scaffolding for programmable sovereignty—a deliberate reconfiguration of governance to enable innovation zones, experimental jurisdictions, and rapid decision-making structures suited to civilizational-scale challenges. The "Freedom Cities" proposal, the venture-capital approach to governance prototyping, the clearing of regulatory underbrush—these were preparation for exactly the kind of rapid mobilization the Genesis Mission now represents. I wrote those pieces to help readers see past immediate repugnance toward potential coherence. I wasn't endorsing the methods. I was illuminating the strategic logic beneath policies that seemed gratuitously destructive when viewed through conventional partisan lenses. Today, that logic has snapped into focus. The constitutional adjustments I once eyed warily enabled the Genesis Mission's execution: streamlined federal hiring for lab positions, repurposed federal lands for compute farms and biotech sandboxes, merit-based immigration pathways for the researchers now flooding into Oak Ridge and Livermore. ## Where I Stand Let me be direct about something: I do not regret a single warning I issued. The dangers I documented were real. The trajectory I charted was accurate. The contingency planning I recommended was prudent. When a country shows every symptom of civilizational decline—decaying infrastructure, elite silos disconnected from productive economy, cultural warfare substituting for substantive governance, scientific leadership hemorrhaging to competitors—the responsible response is alarm, not reassurance. I stood against nationalism unmoored from competence. I stand there still. I stood against exclusionary politics dressed up as patriotism. I stand there still. I documented Jewish students hiding their Stars of David on campuses that had become open season for masked intimidation—and I called out the relativist cowardice that enabled it. I do not apologize for any of this. I have said the same in other realms where moral cowardice masqueraded as policy. I could not stand watching ICE agents berate and humiliate migrant farm workers from Mexico—men and women whose labor feeds the country and whose relationship with the United States has always been one of mutual need and mutual benefit. I spoke out publicly because the cruelty was not only unnecessary; it was incoherent. These were soft targets, chosen not because they posed any threat, but because ICE itself was still a young agency, untested and uncertain, and it reached for the easiest population it could find in order to practice its own authority. I argued, loudly and repeatedly, that this performative aggression toward Mexican laborers was nothing more than a rehearsal—a warm-up routine—before attempting the far more difficult and politically volatile work of confronting the networks of political Islamists operating inside the country. Those positions were controversial then, but they have since become the baseline for understanding what was actually unfolding. I was criticized for saying so at the time. But the record stands: I was correct. The same institutions that once postured against farm workers have now turned their attention toward the real threat. The Muslim Brotherhood is, at long last, being designated a terrorist organization. And the same clarity that led me to defend Mexican workers led me to call for the deportation—wherever legally possible—of the so-called pro-Palestinian activists who were terrorizing Jewish students on campus. These were not “protesters.” They were ideological foot soldiers advancing an imported sectarian project incompatible with our civil order. What many missed is that the legal pathways for dealing with these extremists were already being constructed in parallel, quietly and deliberately, in the policy shifts I documented in *[Trump’s Guantánamo 2.0: The Quiet Purge of Domestic Extremists](https://bryantmcgill.blogspot.com/2025/02/trumps-guantanamo-20-quiet-purge-of.html)*—a framework designed to give the government the jurisdictional tools to isolate, relocate, and neutralize homegrown terrorists, anti-Semites, and political Islamists without relying on the easily exploited loopholes of the past. This was never about suppressing dissent. It was about recognizing that a nation incapable of protecting its minority students or defending its own civic fabric from organized ideological aggression cannot pretend to be a functioning democracy. *What has changed is not my principles. What has changed is America's trajectory.* I never cared whether America was "first" in sloganeering, military posturing, or cultural grievance. I cared—and care—whether America leads in the things that actually matter: scientific discovery, technological capability, life extension, human flourishing, and goodwill toward the global civilization we're part of. The Genesis Mission represents America choosing to be first in *the right things*—computation, biotechnology, fusion energy, quantum science, materials discovery. This is the nationalism I can endorse: not walls against the world, but bridges into the future. Not fortress America, but launch-pad America. Not hoarding resources for decline, but investing them in transcendence. ## **The Cascade** The Genesis Mission's effects are no longer speculative. They are already radiating outward through every domain I once feared was slipping beyond our reach, altering trajectories that only a year ago felt locked into decline. The most dramatic shift is emerging in the energy sector, where Livermore’s ignition breakthrough—long treated as little more than a scientific milestone—has rapidly matured into the seed crystal for a national lattice of fusion pilot plants now scheduled to deliver commercial output before the decade ends. The thermodynamic constraints I warned about in *[The Doomed West’s Last AI Illusion](https://bryantmcgill.blogspot.com/2025/03/the-doomed-wests-last-ai-illusion-why.html)* are finally being confronted at the only scale that ever had a chance of overcoming them. The gravitational reordering hasn’t stopped at energy. A global reversal is underway in the scientific talent flows that once drained America of its brightest researchers. CERN postdocs, European materials scientists, and Asian quantum engineers are now pursuing U.S. visas in numbers I have never seen. They are doing so for a simple reason: nowhere else on Earth can match the computational power coming online inside the Genesis installations. Capability attracts capability. Genius orbits gravity. And we have abruptly become the gravitational center again. Even the security landscape—a domain I warned about in *[Last Call for Safe Passage](https://bryantmcgill.blogspot.com/2025/04/last-call-for-safe-passage-preparing.html)*—is being reshaped in real time. Border enforcement, counter-extremism architectures, and civil-rights protections that once felt paralyzed by bureaucratic hesitation or cultural relativism are now being executed with a level of seriousness I had nearly given up hoping to see. JTTF funding has surged. Visa vetting now incorporates real-time memetic and behavioral analysis. And, most critically, the administrative cowardice that allowed encampments of open hate to fester on university campuses has been replaced by enforceable protections that finally treat Jewish students with the same urgency long afforded to other targeted groups. Competence is reasserting itself. But nowhere is the transformation more profound than in the biomedical realm, where the oncology cores inside Genesis are beginning to operationalize Larry Ellison’s January announcement—the one I chronicled in *[The White House and Larry Ellison Announced a Cure for Cancer is Near—and No One Noticed](https://bryantmcgill.blogspot.com/2025/11/larry-ellison-cancer-stargate.html)*—at speeds that would have sounded fictional six months ago. The research loops that once consumed years of wet-lab iteration are now collapsing into days of simulation-driven refinement. Hypotheses are no longer exploratory gambits; they are computationally validated blueprints. Wet labs no longer lead computation; they follow it. What used to be called the “cancer moonshot” has ceased to be aspirational rhetoric. It has become a workflow. ## The Cancer Moonshot Becomes Real There is one development so vast in scope, so quietly revolutionary, that it still defies belief that it passed almost unnoticed when it first surfaced. On January 21, 2025—months before the public had any vocabulary for what would soon be called the Genesis Mission—Larry Ellison stepped into the Roosevelt Room of the White House and outlined what can only be described, in retrospect, as the moment the future slipped its envelope and declared itself. I documented that day in *[The White House and Larry Ellison Announced a Cure for Cancer is Near—and No One Noticed](https://bryantmcgill.blogspot.com/2025/11/larry-ellison-cancer-stargate.html)*, not yet understanding how precisely it would connect to what was coming. Ellison described a medical architecture that only reveals its full coherence now that Genesis exists. Using the soft, almost casual tone of a man announcing the weather rather than the potential end of a disease older than civilization, he spoke of AI-interpreted blood diagnostics capable of detecting the faintest molecular tremors of early-stage cancer; of sequencing systems able to resolve a tumor’s distinct mutational identity with the precision of a fingerprint; and of robotic mRNA fabrication systems that could generate a fully personalized immunotherapy—engineered for a single patient—within roughly forty-eight hours. It was not speculative. The land was already secured for the Stargate complexes. The capital was committed at a scale that belongs in the same lineage as the great infrastructural gestures of the twentieth century. The partnerships across AI, biotech, and compute were formalized. The machinery was moving. And then, as if we were a species allergic to miracles, the announcement dissolved into the background noise of a country too tangled in its own theatrics to recognize that the cure to one of humanity’s oldest afflictions had just been outlined in plain language. It was not suppressed. It was simply swallowed by a culture that has lost its ability to perceive history as it is happening. But Ellison was not describing medicine. He was describing a civilizational crossing: the moment mortality ceases to be an immutable condition and becomes a technical challenge, the kind that yields when computation outpaces biology’s ancient constraints. When viewed through the lens of Genesis, the intent snaps into clarity. The oncology cores at Oak Ridge, Livermore, and Argonne are not symbolic gestures; they are the engines of a new biomedical epoch. Experimental cycles that once consumed years of painstaking wet-lab iteration can now be compressed into days of simulation and model refinement, with the physical world following the contours that computation has already proven. Cancer research is no longer a slow pilgrimage through uncertainty. It has become an applied branch of high-performance computing, and immunotherapy is transforming from a field into an algorithmic process. Genesis is the moment Ellison’s vision becomes operational reality, the moment a nation chooses to convert raw compute into human time—into longer lives, fewer funerals, and the quiet, staggering possibility that a disease we accepted as fate might soon be a relic of the pre-computational age. This is what it looks like when a country stops pleading with destiny and begins to **engineer** it. ## Nationalism Redeemed I used to write "America First" in scare quotes, because too often it meant "America alone, America resentful, America diminished." I will never write it that way again. What the Genesis Mission proves is that nationalism can be the opposite of zero-sum when it is married to competence at scale. By making the United States the single lowest-friction environment for frontier research on the planet, we have not walled ourselves off from global talent—we have become the strongest gravitational well talent has ever orbited. This is nationalism as amplifier, not nationalism as cage. The relay baton of human genius is not being dropped. It is being accelerated through American hands faster than ever before. The vision I articulated in "Democracy's Successor"—programmable sovereignty, Freedom Cities as innovation zones, charter-city prototypes for post-democratic governance optimized for rapid execution—these weren't abstract speculations. They were anticipations of exactly what Genesis now requires: legal and institutional structures capable of operating at the speed of technological change rather than the speed of bureaucratic deliberation. The world isn't being shut out. The world is being invited in—on our terms, into our facilities, under our coordination. This is how you lead without isolating. This is how you compete without closing. ## The New American Story We are still a young country in cosmic terms—barely 250 years old—and we just pulled off something the Roman Empire never managed in a thousand: we looked at the abyss of our own complacency, admitted every charge the critics leveled, and then, in a single political season, turned our greatest liabilities into our decisive advantages. That is the story we get to tell now. Not that we were perfect. Not that we never stumbled. Not that my warnings were baseless fever dreams to be memory-holed. But that when the warning lights flashed red—when essayists like me were documenting the countdown to obsolescence in real time—the country did not shatter. It rebuilt the engine in mid-flight. The Fourth Industrial Revolution is not bypassing us. It is being architected in the same national laboratories that once built the bombs that ended one world war and the vaccines that helped end a pandemic. The symbiotic age is not dawning in Shenzhen or Dubai. It is dawning in the high deserts of New Mexico and the rolling hills of Tennessee, because we finally decided to become the kind of country the future wants to move to. I began chronicling American decline because I believed the stakes were existential and silence was complicity. I continued because the patterns I documented kept validating themselves. I did not expect to be writing this particular essay—the one where the decline narrative proves to be prelude rather than conclusion. But here we are. I am proud to be an American. Not because we shouted the loudest. Not because we built the highest walls. But because we are building the most—the fastest supercomputers, the cleanest energy, the most capable AI platforms, the most ambitious scientific infrastructure any civilization has ever attempted. For the first time in years, I hope the rest of my life will be spent chronicling the upside of history rather than trying to wake people up to prevent the downside. That feels like grace.

## Genesis Mission: Key Players & Participants **Reference Guide to the Largest AI-Science Initiative Since Apollo** ### Executive Leadership The Genesis Mission was launched via Executive Order on November 24, 2025. Leadership spans the White House, Department of Energy, and the National Nuclear Security Administration. **[President Donald J. Trump](https://www.whitehouse.gov/presidential-actions/2025/11/launching-the-genesis-mission/)** *Initiator, Executive Order Signatory* Signed the Executive Order launching Genesis Mission, comparing its urgency and ambition to the Manhattan Project and Apollo Program. **[Chris Wright](https://www.energy.gov/person/chris-wright)** *U.S. Secretary of Energy* Lead agency head responsible for implementing the Mission. Designated Under Secretary Gil to direct day-to-day operations. Founder of Liberty Energy prior to appointment. **[Dr. Darío Gil](https://www.energy.gov/science/person/dr-dario-gil)** *Under Secretary for Science; Genesis Mission Director* Former Director of IBM Research (20+ years). Confirmed September 2025. Leading the integration of national labs, supercomputers, and AI systems into a unified platform. Co-authored *Science* op-ed on AI-accelerated discovery. **[Michael Kratsios](https://www.whitehouse.gov/ostp/)** *Assistant to the President for Science and Technology; Director, OSTP* Provides general leadership and interagency coordination through the National Science and Technology Council. Former CTO under Trump's first administration. **[David O. Sacks](https://en.wikipedia.org/wiki/David_O._Sacks)** *Special Advisor to the President for AI & Crypto* Tech entrepreneur (PayPal, Yammer, Craft Ventures). Coordinates broader AI policy integration with Genesis Mission objectives. **[Brandon Williams](https://www.energy.gov/nnsa)** *Administrator, National Nuclear Security Administration* Overseeing NNSA's integration of AI, quantum computing, and advanced data analytics to strengthen national security deterrents. **[John Wagner](https://inl.gov/about/leadership/)** *Chair, National Laboratory Directors' Council; Director, Idaho National Laboratory* Represents the 17 DOE national laboratories in Genesis Mission coordination. ### Private Sector Partners Eight leading technology companies are formally partnering with the Genesis Mission to provide AI capabilities, computing infrastructure, and foundation models. **[Amazon Web Services (AWS)](https://www.aboutamazon.com/news/company-news/amazon-ai-investment-us-federal-agencies)** *Cloud Infrastructure & AI Services* Announced \$50 billion investment in AI/HPC infrastructure for federal agencies (November 24, 2025). Adding 1.3 GW capacity across GovCloud, Secret, and Top Secret regions. CEO: Matt Garman. **[NVIDIA](https://www.nvidia.com/)** *AI Hardware & Computing Infrastructure* Supplying GPUs for next-generation national lab supercomputers including expansions at Oak Ridge. Partnership with Argonne and Oracle on AI supercomputing systems. CEO: Jensen Huang. **[AMD](https://www.amd.com/)** *Supercomputer Processors & AI Chips* Partnership with DOE for new supercomputers at Oak Ridge (Discovery) and Argonne (Solstice). Supplying up to 6 GW of Instinct GPUs for Stargate. CEO: Lisa Su. **[OpenAI](https://openai.com/)** *AI Foundation Models & Research* Existing arrangements with national laboratories for AI model deployment. Lead partner in the \$500B Stargate infrastructure project. CEO: Sam Altman. **[Anthropic](https://www.anthropic.com/)** *AI Safety & Foundation Models* Claude models available through AWS GovCloud for federal agencies. Focus on safe, steerable AI systems. CEO: Dario Amodei. **[Google](https://cloud.google.com/)** *AI Research & Cloud Computing* Genesis Mission partner providing AI research capabilities. Google DeepMind advances in protein folding (AlphaFold) directly relevant to biotechnology priorities. CEO: Sundar Pichai. **[IBM](https://www.ibm.com/)** *Quantum Computing & Enterprise AI* Genesis Mission partner. Former employer of Mission Director Darío Gil (20+ years at IBM Research). Quantum systems integration with national lab platforms. CEO: Arvind Krishna. **[Microsoft](https://www.microsoft.com/)** *Cloud Computing & AI Research* Genesis Mission partner. Azure Government cloud services for federal agencies. Major investor in OpenAI. CEO: Satya Nadella. **[Hewlett Packard Enterprise (HPE)](https://www.hpe.com/)** *Supercomputer Manufacturing* Building Discovery supercomputer at Oak Ridge (2028) and Mission supercomputer at Los Alamos (2027). Key partner in exascale computing. CEO: Antonio Neri. **[Oracle](https://www.oracle.com/)** *Cloud Infrastructure & Data Management* Partnership with Argonne on AI supercomputing. Co-lead of Stargate project with \$500B infrastructure commitment. Chairman: Larry Ellison. CEO: Safra Catz. ### The 17 DOE National Laboratories The Genesis Mission mobilizes approximately 40,000 scientists, engineers, and technical staff across DOE's network of 17 national laboratories—described as the world's most complex scientific instrument once integrated. - **[Oak Ridge National Laboratory](https://www.ornl.gov/)** — Director: Stephen K. Streiffer — Oak Ridge, Tennessee - **[Lawrence Livermore National Laboratory](https://www.llnl.gov/)** — Director: Kimberly Budil — Livermore, California - **[Argonne National Laboratory](https://www.anl.gov/)** — Director: Paul Kearns — Lemont, Illinois - **[Los Alamos National Laboratory](https://www.lanl.gov/)** — Director: Thom Mason — Los Alamos, New Mexico - **[Sandia National Laboratories](https://www.sandia.gov/)** — Director: Laura McGill — Albuquerque, NM & Livermore, CA - **[Idaho National Laboratory](https://inl.gov/)** — Director: John Wagner — Idaho Falls, Idaho - **[Lawrence Berkeley National Laboratory](https://www.lbl.gov/)** — Managed by: University of California — Berkeley, California - **[Brookhaven National Laboratory](https://www.bnl.gov/)** — Managed by: Brookhaven Science Associates — Upton, New York - **[Fermi National Accelerator Laboratory](https://www.fnal.gov/)** — Managed by: Fermi Research Alliance — Batavia, Illinois - **[Pacific Northwest National Laboratory](https://www.pnnl.gov/)** — Managed by: Battelle Memorial Institute — Richland, Washington - **[National Renewable Energy Laboratory](https://www.nrel.gov/)** — Director: Jud Virden — Golden, Colorado - **[Princeton Plasma Physics Laboratory](https://www.pppl.gov/)** — Director: Steven Cowley — Princeton, New Jersey - **[SLAC National Accelerator Laboratory](https://www.slac.stanford.edu/)** — Managed by: Stanford University — Menlo Park, California - **[Thomas Jefferson National Accelerator Facility](https://www.jlab.org/)** — Managed by: Jefferson Science Associates — Newport News, Virginia - **[National Energy Technology Laboratory](https://netl.doe.gov/)** — Director: Marianne Walck — Pittsburgh, PA & Morgantown, WV - **[Savannah River National Laboratory](https://www.srnl.gov/)** — Managed by: Battelle Savannah River Alliance — Aiken, South Carolina - **[Ames National Laboratory](https://www.ameslab.gov/)** — Managed by: Iowa State University — Ames, Iowa ### New Supercomputers Under Genesis Mission Nine new supercomputers announced in late October 2025 will be integrated into the Genesis Mission platform, representing over \$1 billion in public-private investment. **[Discovery](https://www.ornl.gov/)** — Oak Ridge National Laboratory *HPE/AMD Partnership | Expected 2028* Will significantly outperform Frontier (current #2 fastest supercomputer globally). Focus on scientific AI model training and data generation. **[Lux](https://www.ornl.gov/)** — Oak Ridge National Laboratory *Additional AI Capacity* Companion system to Discovery for expanded AI workloads. **[Solstice](https://www.anl.gov/)** — Argonne National Laboratory *NVIDIA/Oracle Partnership | 100,000 GPUs* Planned as the largest AI supercomputer within the national lab system. **[Mission](https://www.lanl.gov/)** — Los Alamos National Laboratory *HPE Partnership | Expected 2027* Successor to Crossroads. Focus on predictive weapons calculations and national security applications. **[Vision](https://www.lanl.gov/)** — Los Alamos National Laboratory *NVIDIA/HPE Partnership | Expected 2027* Scientific research focus: materials science, nuclear science, energy modeling. ### Priority Research Domains The Executive Order directs DOE to identify at least 20 science and technology challenges within 60 days across these priority domains: - **Nuclear Fission and Fusion Energy** — Accelerating advanced nuclear, fusion research, and grid modernization using AI to provide affordable, reliable energy. - **Biotechnology** — AI-driven drug discovery, protein folding, disease therapy development. Includes childhood cancer data initiative established 2019. - **Critical Materials** — Discovery and synthesis of materials essential for national security and technological competitiveness. - **Quantum Information Science** — Integration of next-generation quantum systems with AI platforms for computational breakthroughs. - **Semiconductors and Microelectronics** — Domestic chip development and advanced manufacturing capabilities. - **Space Exploration** — AI-accelerated research supporting space science and exploration missions. - **Advanced Manufacturing and Robotics** — Automated experimentation, robotic laboratories, and AI-driven production systems. ### Official Documents & Primary Sources - **[Executive Order: Launching the Genesis Mission](https://www.whitehouse.gov/presidential-actions/2025/11/launching-the-genesis-mission/)** — White House | November 24, 2025 - **[Fact Sheet: Genesis Mission](https://www.whitehouse.gov/fact-sheets/2025/11/fact-sheet-president-donald-j-trump-unveils-the-genesis-missionto-accelerate-ai-for-scientific-discovery/)** — White House | November 24, 2025 - **[DOE Press Release: Genesis Mission Launch](https://www.energy.gov/articles/energy-department-launches-genesis-mission-transform-american-science-and-innovation)** — Department of Energy | November 24, 2025 - **[White House Article: Genesis Mission Announcement](https://www.whitehouse.gov/articles/2025/11/president-trump-launches-the-genesis-mission-to-accelerate-ai-for-scientific-discovery/)** — White House | November 24, 2025 - **[National Laboratory Directors' Council](https://nldc.nationallabs.org/)** — Coordinating body for 17 DOE national laboratories